| 09/02/06 | hosting | Cumberlands KY | 9-21 |
| 09/09/06 | at | Chowan | 23-20 |
| 09/23/06 | hosting | Bethel TN | 7-26 |
| 09/30/06 | hosting | Pikeville | 39-17 |
| 10/07/06 | at | Belhaven | 23-26 |
| 10/14/06 | at | Lambuth | 3-9 |
| 10/21/06 | hosting | Frostburg St | 3-7 |
| 10/28/06 | hosting | Georgetown KY | 14-42 |
| 11/04/06 | at | West Virginia Tech | 37-43 |
| 11/11/06 | at | Virginia-Wise | 6-21 |