| 09/02/06 | hosting | John Carroll | 30-22 |
| 09/09/06 | at | Waynesburg | 31-10 |
| 09/23/06 | hosting | Case Western Reserve | 21-7 |
| 09/30/06 | hosting | Wittenberg | 21-24 |
| 10/07/06 | at | Ohio Wesleyan | 24-0 |
| 10/14/06 | at | Hiram | 52-0 |
| 10/21/06 | hosting | Allegheny | 27-21 |
| 10/28/06 | at | Wabash | 10-20 |
| 11/04/06 | hosting | Earlham | 38-31 |
| 11/11/06 | at | Kenyon | 41-13 |