| 11/26/05 | hosting | Youngstown St. | 67-62 |
| 11/30/05 | hosting | Duquesne | 79-61 |
| 12/03/05 | at | California | 75-89 |
| 12/07/05 | hosting | Denison | 123-52 |
| 12/10/05 | at | Louisville | 85-111 |
| 12/19/05 | vs. | Mount St. Mary's | 74-61 |
| 12/20/05 | vs. | Mississippi St. | 83-72 |
| 12/21/05 | vs. | Clemson | 59-66 |
| 12/31/05 | hosting | Wright St. | 72-44 |
| 01/04/06 | at | Ball St. | 66-62 |
| 01/07/06 | hosting | Toledo | 75-58 |
| 01/10/06 | at | Western Michigan | 69-55 |
| 01/14/06 | hosting | Northern Illinois | 86-73 |
| 01/16/06 | at | Cleveland St. | 62-50 |
| 01/18/06 | at | Central Michigan | 76-69 OT |
| 01/21/06 | hosting | Eastern Michigan | 79-61 |
| 01/24/06 | at | Ohio | 63-66 |
| 01/26/06 | hosting | Miami OH | 52-45 |
| 01/29/06 | at | Bowling Green | 77-72 OT |
| 02/01/06 | hosting | Buffalo | 75-61 |
| 02/04/06 | at | Kent St. | 57-63 |
| 02/08/06 | hosting | Western Michigan | 75-53 |
| 02/11/06 | at | Eastern Michigan | 77-72 |
| 02/14/06 | hosting | Bowling Green | 77-62 |
| 02/17/06 | at | Nevada | 61-88 |
| 02/22/06 | at | Miami OH | 60-63 |
| 02/25/06 | hosting | Ohio | 76-61 |
| 03/01/06 | at | Buffalo | 71-83 |
| 03/04/06 | hosting | Kent St. | 75-67 |
| 03/09/06 | vs. | Western Michigan | 72-57 |
| 03/10/06 | vs. | Toledo | 69-77 |
| 03/14/06 | at | Temple | 80-73 OT |
| 03/16/06 | at | Creighton | 60-71 |