| 11/18/05 | hosting | Dartmouth | 80-61 |
| 11/20/05 | hosting | Shawnee St. | 70-51 |
| 11/22/05 | hosting | Buffalo | 92-63 |
| 11/25/05 | vs. | Drake | 87-84 |
| 11/26/05 | vs. | Oklahoma St. | 76-68 |
| 12/03/05 | hosting | Sacred Heart | 77-66 |
| 12/06/05 | vs. | Michigan St. | 70-77 |
| 12/11/05 | at | Maryland | 71-73 |
| 12/18/05 | hosting | Texas Southern | 80-53 |
| 12/22/05 | hosting | Harvard | 89-55 |
| 12/27/05 | at | Duquesne | 81-69 |
| 12/31/05 | at | Rhode Island | 78-56 |
| 01/03/06 | hosting | Massachusetts | 91-62 |
| 01/08/06 | at | Georgia Tech | 58-60 |
| 01/10/06 | hosting | North Carolina St. | 60-78 |
| 01/14/06 | hosting | Florida St. | 90-87 |
| 01/17/06 | at | Holy Cross | 63-53 |
| 01/21/06 | at | Miami FL | 65-61 |
| 01/25/06 | at | North Carolina | 81-74 |
| 01/29/06 | hosting | Georgia Tech | 66-64 |
| 02/01/06 | hosting | Duke | 81-83 |
| 02/04/06 | at | Virginia Tech | 74-73 |
| 02/08/06 | at | Wake Forest | 72-66 |
| 02/11/06 | hosting | Clemson | 67-61 |
| 02/13/06 | hosting | Stony Brook | 59-47 |
| 02/16/06 | hosting | Miami FL | 65-54 |
| 02/21/06 | at | Virginia | 58-72 |
| 02/25/06 | at | North Carolina St. | 74-72 2OT |
| 02/28/06 | hosting | Wake Forest | 80-65 |
| 03/04/06 | hosting | Virginia Tech | 59-57 |
| 03/10/06 | vs. | Maryland | 80-66 |
| 03/11/06 | vs. | North Carolina | 85-82 |
| 03/12/06 | vs. | Duke | 76-78 |
| 03/16/06 | vs. | Pacific | 88-76 2OT |
| 03/18/06 | vs. | Montana | 69-56 |
| 03/24/06 | vs. | Villanova | 59-60 OT |