| 11/19/05 | at | DePaul | 75-60 |
| 11/26/05 | hosting | Chicago St. | 68-58 |
| 11/30/05 | at | Loyola Chicago | 72-86 |
| 12/03/05 | hosting | Bowling Green | 93-64 |
| 12/06/05 | at | Butler | 60-70 |
| 12/14/05 | hosting | Western Kentucky | 78-76 |
| 12/17/05 | hosting | Delaware St. | 68-46 |
| 12/21/05 | at | Southern Mississippi | 56-43 |
| 12/28/05 | hosting | Northern Iowa | 68-60 OT |
| 12/30/05 | at | Wichita St. | 67-69 OT |
| 01/02/06 | hosting | Creighton | 86-69 |
| 01/05/06 | at | Drake | 73-75 |
| 01/08/06 | at | Southern Illinois | 55-67 |
| 01/11/06 | hosting | Wichita St. | 76-86 |
| 01/14/06 | hosting | Evansville | 90-62 |
| 01/18/06 | at | Creighton | 76-80 |
| 01/21/06 | hosting | Indiana St. | 85-63 |
| 01/25/06 | hosting | Missouri St. | 86-76 |
| 01/28/06 | at | Evansville | 79-76 OT |
| 02/01/06 | hosting | Illinois St. | 73-44 |
| 02/04/06 | at | Missouri St. | 62-70 |
| 02/08/06 | at | Indiana St. | 63-75 |
| 02/11/06 | at | Illinois St. | 71-59 |
| 02/14/06 | hosting | Southern Illinois | 72-60 |
| 02/18/06 | hosting | Tennessee Tech | 77-62 |
| 02/22/06 | at | Northern Iowa | 71-49 |
| 02/25/06 | hosting | Drake | 86-66 |
| 03/03/06 | vs. | Creighton | 54-47 |
| 03/04/06 | vs. | Wichita St. | 60-52 |
| 03/05/06 | vs. | Southern Illinois | 46-59 |
| 03/17/06 | vs. | Kansas | 77-73 |
| 03/19/06 | vs. | Pittsburgh | 72-66 |
| 03/23/06 | vs. | Memphis | 64-80 |