| 11/18/05 | at | Rider | 56-54 |
| 11/22/05 | at | Syracuse | 74-69 |
| 11/26/05 | hosting | Yale | 87-60 |
| 11/30/05 | at | Niagara | 66-63 |
| 12/03/05 | at | DePaul | 57-52 |
| 12/06/05 | hosting | Villanova | 60-79 |
| 12/17/05 | hosting | Cornell | 83-39 |
| 12/19/05 | hosting | Haverford | 76-44 |
| 12/21/05 | hosting | Saint Joseph's | 63-51 |
| 12/28/05 | vs. | Boston University | 63-57 |
| 12/29/05 | at | Santa Clara | 68-77 |
| 01/02/06 | at | Duke | 50-84 |
| 01/07/06 | at | Navy | 74-52 |
| 01/11/06 | at | American | 58-50 |
| 01/14/06 | hosting | Holy Cross | 56-42 |
| 01/18/06 | hosting | Lafayette | 62-32 |
| 01/21/06 | hosting | Colgate | 62-43 |
| 01/25/06 | at | Lehigh | 59-54 |
| 01/28/06 | hosting | Navy | 81-47 |
| 02/01/06 | at | Army | 67-54 |
| 02/04/06 | at | Colgate | 68-59 |
| 02/08/06 | hosting | American | 74-57 |
| 02/11/06 | at | Holy Cross | 57-52 |
| 02/15/06 | at | Lafayette | 69-49 |
| 02/18/06 | at | Northern Iowa | 61-65 2OT |
| 02/22/06 | hosting | Lehigh | 81-70 |
| 02/25/06 | hosting | Army | 70-47 |
| 03/03/06 | hosting | Army | 59-47 |
| 03/05/06 | hosting | American | 64-50 |
| 03/10/06 | hosting | Holy Cross | 74-59 |
| 03/17/06 | vs. | Arkansas | 59-55 |
| 03/19/06 | vs. | Memphis | 56-72 |