| 11/18/05 | hosting | Bethune Cookman | 84-55 |
| 11/21/05 | hosting | Coppin St. | 102-71 |
| 11/23/05 | hosting | South Carolina St. | 79-38 |
| 11/26/05 | at | Charleston Southern | 68-56 |
| 11/29/05 | at | Penn St. | 96-88 |
| 12/03/05 | hosting | South Carolina | 82-63 |
| 12/06/05 | hosting | Wofford | 62-60 |
| 12/09/05 | hosting | East Tennessee St. | 80-72 |
| 12/19/05 | at | Puerto Rico Mayaguez | 101-60 |
| 12/20/05 | vs. | Holy Cross | 71-48 |
| 12/21/05 | vs. | Akron | 66-59 |
| 12/28/05 | at | Georgia | 69-72 |
| 12/30/05 | hosting | Elon | 69-74 |
| 01/04/06 | hosting | Florida St. | 61-55 |
| 01/07/06 | at | Virginia | 58-64 |
| 01/11/06 | hosting | Wake Forest | 74-73 OT |
| 01/14/06 | hosting | Duke | 77-87 |
| 01/18/06 | at | Miami FL | 38-62 |
| 01/21/06 | at | Georgia Tech | 73-63 |
| 01/29/06 | hosting | North Carolina St. | 85-94 2OT |
| 02/01/06 | at | Florida St. | 59-69 |
| 02/04/06 | at | North Carolina | 61-76 |
| 02/08/06 | hosting | Virginia Tech | 74-75 OT |
| 02/11/06 | at | Boston College | 61-67 |
| 02/14/06 | hosting | Maryland | 89-77 |
| 02/22/06 | at | Wake Forest | 68-74 OT |
| 02/25/06 | hosting | Virginia | 90-64 |
| 03/01/06 | at | Virginia Tech | 86-81 |
| 03/04/06 | hosting | Georgia Tech | 95-82 |
| 03/09/06 | vs. | Miami FL | 63-66 |
| 03/15/06 | hosting | Louisiana Tech | 69-53 |
| 03/20/06 | at | Louisville | 68-74 |