| 11/19/05 | hosting | Bradley | 60-75 |
| 11/26/05 | hosting | Northwestern | 59-49 |
| 11/28/05 | at | Northern Illinois | 68-77 |
| 11/30/05 | hosting | Creighton | 72-57 |
| 12/03/05 | hosting | Bucknell | 52-57 |
| 12/06/05 | hosting | UAB | 70-66 |
| 12/10/05 | at | Dayton | 61-54 |
| 12/13/05 | at | Wake Forest | 84-81 |
| 12/17/05 | at | Old Dominion | 43-87 |
| 12/21/05 | vs. | California | 68-65 |
| 12/31/05 | hosting | Florida International | 72-60 |
| 01/04/06 | at | Cincinnati | 60-82 |
| 01/07/06 | hosting | Notre Dame | 73-67 |
| 01/12/06 | at | Pittsburgh | 65-73 |
| 01/15/06 | hosting | Rutgers | 68-78 OT |
| 01/17/06 | hosting | Marquette | 79-82 |
| 01/21/06 | at | Providence | 75-76 |
| 01/25/06 | at | Marquette | 47-62 |
| 01/31/06 | hosting | Georgetown | 44-64 |
| 02/03/06 | at | South Florida | 80-66 |
| 02/07/06 | hosting | Providence | 60-61 |
| 02/11/06 | hosting | Villanova | 51-61 |
| 02/18/06 | at | St. John's | 52-48 |
| 02/22/06 | at | Louisville | 53-65 |
| 02/25/06 | hosting | Seton Hall | 67-64 |
| 03/02/06 | hosting | Syracuse | 108-69 |
| 03/04/06 | at | Notre Dame | 61-66 |