| 11/18/05 | at | Navy | 72-49 |
| 11/21/05 | at | James Madison | 73-66 |
| 11/26/05 | hosting | Vanderbilt | 61-68 |
| 12/03/05 | at | Oregon | 71-57 |
| 12/08/05 | at | Illinois | 48-58 |
| 12/11/05 | hosting | Fairfield | 76-51 |
| 12/17/05 | hosting | Stetson | 70-50 |
| 12/21/05 | hosting | Savannah St. | 78-49 |
| 12/27/05 | vs. | Colgate | 61-45 |
| 12/28/05 | at | Texas El Paso | 76-64 |
| 01/05/06 | hosting | Providence | 72-62 |
| 01/08/06 | at | St. John's | 79-65 |
| 01/11/06 | at | West Virginia | 61-68 |
| 01/14/06 | at | Connecticut | 67-74 |
| 01/17/06 | hosting | South Florida | 50-47 |
| 01/21/06 | hosting | Duke | 87-84 |
| 01/24/06 | at | Notre Dame | 85-82 2OT |
| 01/28/06 | hosting | Cincinnati | 76-57 |
| 01/31/06 | at | DePaul | 64-44 |
| 02/05/06 | hosting | Pittsburgh | 61-58 |
| 02/09/06 | hosting | St. John's | 64-41 |
| 02/12/06 | hosting | West Virginia | 56-69 |
| 02/16/06 | at | Marquette | 51-57 |
| 02/19/06 | at | Villanova | 65-75 |
| 02/22/06 | hosting | Rutgers | 66-50 |
| 02/25/06 | hosting | Syracuse | 68-53 |
| 03/04/06 | at | South Florida | 56-63 |
| 03/08/06 | vs. | Notre Dame | 67-63 |
| 03/09/06 | vs. | Marquette | 62-59 |
| 03/10/06 | vs. | Syracuse | 57-58 |
| 03/17/06 | vs. | Northern Iowa | 54-49 |
| 03/19/06 | vs. | Ohio St. | 70-52 |
| 03/24/06 | vs. | Florida | 53-57 |