| 11/18/05 | hosting | South Dakota St. | 90-65 |
| 11/20/05 | hosting | Texas Pan American | 71-59 |
| 11/22/05 | hosting | Texas Southern | 93-59 |
| 11/25/05 | vs. | Wichita St. | 55-54 |
| 11/26/05 | vs. | Rutgers | 77-57 |
| 11/29/05 | at | North Carolina | 68-64 |
| 12/03/05 | vs. | Xavier | 65-62 |
| 12/05/05 | hosting | Arkansas Little Rock | 75-49 |
| 12/08/05 | hosting | Georgetown | 58-48 |
| 12/10/05 | vs. | Oregon | 89-59 |
| 12/18/05 | hosting | Coppin St. | 61-42 |
| 12/21/05 | vs. | Missouri | 82-50 |
| 12/28/05 | hosting | Southeast Missouri St. | 89-64 |
| 12/30/05 | hosting | Tennessee Martin | 84-46 |
| 01/05/06 | hosting | Michigan St. | 60-50 |
| 01/07/06 | at | Iowa | 48-63 |
| 01/14/06 | hosting | Michigan | 79-74 |
| 01/17/06 | at | Indiana | 60-62 |
| 01/21/06 | at | Northwestern | 58-47 |
| 01/25/06 | hosting | Minnesota | 77-53 |
| 01/28/06 | hosting | Purdue | 76-58 |
| 01/31/06 | at | Wisconsin | 66-51 |
| 02/04/06 | hosting | Penn St. | 65-66 |
| 02/12/06 | at | Ohio St. | 53-69 |
| 02/15/06 | hosting | Northwestern | 63-47 |
| 02/19/06 | hosting | Indiana | 70-58 |
| 02/21/06 | at | Michigan | 64-72 |
| 02/25/06 | hosting | Iowa | 71-59 |
| 02/28/06 | at | Minnesota | 71-65 |
| 03/04/06 | at | Michigan St. | 75-68 |
| 03/10/06 | vs. | Michigan St. | 56-61 |
| 03/16/06 | vs. | Air Force | 78-69 |
| 03/18/06 | vs. | Washington | 64-67 |