| 11/14/05 | hosting | Maryland Eastern Shore | 86-41 |
| 11/15/05 | hosting | Colgate | 73-51 |
| 11/21/05 | vs. | Kentucky | 67-63 |
| 11/22/05 | vs. | Texas | 59-68 |
| 11/26/05 | hosting | Texas San Antonio | 79-46 |
| 11/30/05 | hosting | North Carolina St. | 45-42 |
| 12/02/05 | hosting | Fairfield | 75-59 |
| 12/03/05 | hosting | Valparaiso | 72-59 |
| 12/06/05 | at | Northern Iowa | 63-67 OT |
| 12/09/05 | at | Iowa St. | 60-72 |
| 12/17/05 | hosting | Arizona St. | 62-43 |
| 12/20/05 | hosting | Drake | 65-60 |
| 12/22/05 | hosting | Robert Morris | 73-51 |
| 12/30/05 | at | St. Louis | 60-50 |
| 01/05/06 | at | Wisconsin | 52-66 |
| 01/07/06 | hosting | Illinois | 63-48 |
| 01/14/06 | at | Penn St. | 80-76 |
| 01/18/06 | hosting | Minnesota | 76-72 3OT |
| 01/21/06 | at | Michigan St. | 55-85 |
| 01/24/06 | hosting | Indiana | 73-60 |
| 01/28/06 | hosting | Ohio St. | 67-62 |
| 02/01/06 | at | Purdue | 77-68 |
| 02/04/06 | hosting | Michigan | 94-66 |
| 02/08/06 | at | Northwestern | 48-51 |
| 02/11/06 | at | Indiana | 70-67 |
| 02/14/06 | hosting | Michigan St. | 66-54 |
| 02/18/06 | at | Minnesota | 61-74 |
| 02/25/06 | at | Illinois | 59-71 |
| 03/01/06 | hosting | Penn St. | 65-38 |
| 03/04/06 | hosting | Wisconsin | 59-44 |
| 03/10/06 | vs. | Minnesota | 67-57 |
| 03/11/06 | vs. | Michigan St. | 53-48 |
| 03/12/06 | vs. | Ohio St. | 67-60 |
| 03/17/06 | vs. | Northwestern St. | 63-64 |