| 11/21/05 | hosting | Delaware St. | 56-65 |
| 11/22/05 | hosting | Austin Peay | 94-67 |
| 11/25/05 | vs. | Rutgers | 52-55 |
| 11/26/05 | vs. | Texas Pan American | 82-70 |
| 11/30/05 | at | Youngstown St. | 77-69 |
| 12/03/05 | hosting | Cleveland St. | 83-68 |
| 12/08/05 | hosting | IUPU Fort Wayne | 86-61 |
| 12/10/05 | at | Southern Illinois | 51-58 |
| 12/21/05 | vs. | Concordia CA | 88-76 |
| 12/22/05 | at | St. Mary's | 59-61 |
| 12/30/05 | at | Syracuse | 66-78 |
| 01/04/06 | hosting | Toledo | 76-68 |
| 01/07/06 | at | Central Michigan | 66-60 |
| 01/11/06 | hosting | Ball St. | 84-71 |
| 01/14/06 | at | Eastern Michigan | 74-64 |
| 01/17/06 | hosting | Western Michigan | 77-62 |
| 01/21/06 | at | Northern Illinois | 72-61 |
| 01/24/06 | at | Miami OH | 53-46 |
| 01/26/06 | hosting | Bowling Green | 74-79 |
| 01/29/06 | hosting | Buffalo | 70-52 |
| 02/01/06 | at | Ohio | 73-60 |
| 02/04/06 | hosting | Akron | 63-57 |
| 02/07/06 | at | Toledo | 44-60 |
| 02/12/06 | hosting | Northern Illinois | 67-55 |
| 02/15/06 | at | Buffalo | 111-107 2OT |
| 02/18/06 | hosting | Butler | 80-76 OT |
| 02/21/06 | at | Bowling Green | 82-66 |
| 02/25/06 | hosting | Miami OH | 70-63 |
| 02/28/06 | hosting | Ohio | 78-58 |
| 03/04/06 | at | Akron | 67-75 |
| 03/09/06 | vs. | Buffalo | 76-67 |
| 03/10/06 | vs. | Ohio | 72-59 |
| 03/11/06 | vs. | Toledo | 71-66 |
| 03/17/06 | vs. | Pittsburgh | 64-79 |