| 11/18/05 | hosting | Rice | 82-65 |
| 11/19/05 | hosting | Winthrop | 64-71 |
| 11/23/05 | vs. | Eastern Washington | 83-73 |
| 11/25/05 | vs. | Oral Roberts | 73-70 |
| 11/26/05 | vs. | South Carolina | 92-89 OT |
| 11/30/05 | at | Nebraska | 74-84 |
| 12/03/05 | hosting | South Dakota St. | 87-52 |
| 12/07/05 | hosting | Valparaiso | 69-54 |
| 12/10/05 | at | Wisconsin | 63-77 |
| 12/17/05 | hosting | San Francisco | 61-48 |
| 12/19/05 | hosting | Oakland | 90-69 |
| 12/22/05 | hosting | Delaware St. | 60-48 |
| 12/28/05 | hosting | Lewis | 88-40 |
| 01/03/06 | hosting | Connecticut | 94-79 |
| 01/07/06 | hosting | Cincinnati | 66-70 |
| 01/11/06 | at | Seton Hall | 67-63 |
| 01/14/06 | at | West Virginia | 85-104 |
| 01/17/06 | at | DePaul | 82-79 |
| 01/20/06 | hosting | Notre Dame | 67-65 |
| 01/25/06 | hosting | DePaul | 62-47 |
| 01/28/06 | at | Pittsburgh | 71-77 |
| 02/01/06 | hosting | St. John's | 81-61 |
| 02/04/06 | at | Villanova | 67-72 |
| 02/12/06 | at | Rutgers | 84-91 |
| 02/16/06 | hosting | Georgetown | 57-51 |
| 02/18/06 | hosting | Pittsburgh | 84-82 |
| 02/25/06 | at | Notre Dame | 80-72 |
| 03/01/06 | at | Louisville | 60-67 OT |
| 03/04/06 | hosting | Providence | 88-78 |
| 03/09/06 | vs. | Georgetown | 59-62 |
| 03/16/06 | vs. | Alabama | 85-90 |