| 11/13/05 | vs. | Texas Arlington | 76-65 |
| 11/14/05 | vs. | Air Force | 53-57 |
| 11/15/05 | vs. | Wisconsin Green Bay | 80-54 |
| 11/19/05 | hosting | Morgan St. | 83-51 |
| 11/22/05 | hosting | North Carolina A&T | 87-62 |
| 11/27/05 | at | Temple | 56-73 |
| 11/29/05 | at | Michigan | 53-74 |
| 12/03/05 | hosting | Birmingham Southern | 82-55 |
| 12/10/05 | hosting | Wofford | 71-40 |
| 12/18/05 | at | North Carolina St. | 69-81 |
| 12/22/05 | hosting | Florida | 67-77 |
| 12/27/05 | hosting | Stetson | 65-56 |
| 12/31/05 | vs. | Louisville | 43-58 |
| 01/02/06 | hosting | Sacred Heart | 63-57 |
| 01/07/06 | hosting | Maryland | 84-70 |
| 01/14/06 | at | North Carolina | 81-70 |
| 01/18/06 | hosting | Clemson | 62-38 |
| 01/21/06 | hosting | Boston College | 61-65 |
| 01/24/06 | at | Virginia | 51-71 |
| 01/29/06 | at | Florida St. | 84-78 OT |
| 01/31/06 | hosting | Wake Forest | 78-69 |
| 02/04/06 | at | Georgia Tech | 70-53 |
| 02/08/06 | hosting | North Carolina St. | 77-86 2OT |
| 02/12/06 | hosting | North Carolina | 70-80 |
| 02/16/06 | at | Boston College | 54-65 |
| 02/19/06 | at | Duke | 71-92 |
| 02/22/06 | hosting | Virginia Tech | 70-59 |
| 03/01/06 | at | Maryland | 61-65 |
| 03/05/06 | hosting | Florida St. | 64-67 |
| 03/09/06 | vs. | Clemson | 66-63 |
| 03/10/06 | vs. | Duke | 76-80 |
| 03/15/06 | hosting | Oklahoma St. | 62-59 |
| 03/20/06 | at | Creighton | 53-52 |
| 03/22/06 | at | Michigan | 65-71 |