| 11/18/05 | hosting | Central Michigan | 87-60 |
| 11/22/05 | at | Boston University | 51-46 |
| 11/26/05 | hosting | Butler | 78-74 |
| 11/29/05 | hosting | Miami FL | 74-53 |
| 12/03/05 | at | Notre Dame | 71-67 |
| 12/07/05 | hosting | Delaware St. | 69-49 |
| 12/10/05 | at | South Florida | 68-47 |
| 12/17/05 | hosting | UCLA | 61-68 |
| 12/22/05 | hosting | Miami OH | 87-80 |
| 12/28/05 | hosting | Coppin St. | 81-53 |
| 12/31/05 | hosting | Chicago St. | 86-69 |
| 01/03/06 | at | Indiana | 63-70 |
| 01/07/06 | hosting | Purdue | 68-65 |
| 01/14/06 | at | Illinois | 74-79 |
| 01/18/06 | hosting | Northwestern | 68-51 |
| 01/21/06 | at | Minnesota | 71-55 |
| 01/25/06 | hosting | Michigan St. | 72-67 |
| 01/28/06 | hosting | Wisconsin | 85-76 |
| 02/01/06 | at | Penn St. | 71-65 |
| 02/04/06 | at | Iowa | 66-94 |
| 02/09/06 | hosting | Ohio St. | 85-94 |
| 02/11/06 | at | Purdue | 70-84 |
| 02/15/06 | hosting | Minnesota | 72-50 |
| 02/18/06 | at | Michigan St. | 71-90 |
| 02/21/06 | hosting | Illinois | 72-64 |
| 02/25/06 | at | Ohio St. | 54-64 |
| 03/04/06 | hosting | Indiana | 67-69 |
| 03/09/06 | vs. | Minnesota | 55-59 |
| 03/16/06 | hosting | Texas El Paso | 82-67 |
| 03/20/06 | hosting | Notre Dame | 87-84 2OT |
| 03/22/06 | hosting | Miami FL | 71-65 |
| 03/28/06 | vs. | Old Dominion | 66-43 |
| 03/30/06 | vs. | South Carolina | 64-76 |