| 11/19/05 | at | Hawaii | 62-84 |
| 11/21/05 | at | Chaminade | 89-67 |
| 11/22/05 | vs. | Gonzaga | 106-109 3OT |
| 11/23/05 | vs. | Arizona | 74-71 OT |
| 11/27/05 | hosting | IUPU Fort Wayne | 84-73 |
| 11/30/05 | hosting | Georgia Tech | 88-86 |
| 12/03/05 | vs. | Arkansas Little Rock | 72-67 |
| 12/06/05 | vs. | Boston College | 77-70 |
| 12/10/05 | vs. | Wichita St. | 83-64 |
| 12/16/05 | hosting | Cleveland St. | 83-75 |
| 12/18/05 | hosting | Florida International | 85-58 |
| 12/21/05 | at | Wisconsin Green Bay | 98-69 |
| 12/28/05 | hosting | Tennessee Tech | 80-63 |
| 12/31/05 | hosting | Coppin St. | 78-54 |
| 01/05/06 | at | Illinois | 50-60 |
| 01/08/06 | at | Wisconsin | 63-82 |
| 01/11/06 | hosting | Indiana | 87-73 |
| 01/15/06 | at | Ohio St. | 62-59 2OT |
| 01/21/06 | hosting | Iowa | 85-55 |
| 01/25/06 | at | Michigan | 67-72 |
| 01/28/06 | hosting | Penn St. | 69-60 |
| 02/04/06 | at | Northwestern | 77-66 |
| 02/08/06 | hosting | Purdue | 77-52 |
| 02/11/06 | at | Minnesota | 55-69 |
| 02/14/06 | at | Iowa | 54-66 |
| 02/18/06 | hosting | Michigan | 90-71 |
| 02/22/06 | hosting | Ohio St. | 68-79 |
| 02/26/06 | at | Indiana | 71-78 |
| 03/02/06 | hosting | Wisconsin | 74-65 |
| 03/04/06 | hosting | Illinois | 68-75 |
| 03/09/06 | vs. | Purdue | 70-58 |
| 03/10/06 | vs. | Illinois | 61-56 |
| 03/11/06 | vs. | Iowa | 48-53 |
| 03/17/06 | vs. | George Mason | 65-75 |