| 11/18/05 | hosting | Stetson | 91-61 |
| 11/19/05 | hosting | The Citadel | 91-59 |
| 11/20/05 | hosting | Delaware | 73-57 |
| 11/23/05 | hosting | Virginia Military Inst | 75-55 |
| 11/26/05 | vs. | Notre Dame | 61-48 |
| 11/30/05 | at | Iowa | 42-45 |
| 12/10/05 | hosting | Appalachian St. | 92-68 |
| 12/14/05 | hosting | NC Asheville | 86-56 |
| 12/18/05 | hosting | Miami FL | 81-69 |
| 12/22/05 | at | Alabama | 68-64 |
| 12/28/05 | hosting | New Hampshire | 81-62 |
| 12/30/05 | hosting | George Washington | 79-58 |
| 01/03/06 | hosting | NC Greensboro | 83-52 |
| 01/07/06 | at | North Carolina | 69-82 |
| 01/10/06 | at | Boston College | 78-60 |
| 01/14/06 | hosting | Georgia Tech | 87-78 |
| 01/18/06 | at | Duke | 68-81 |
| 01/21/06 | hosting | Wake Forest | 92-82 |
| 01/25/06 | hosting | Seton Hall | 65-83 |
| 01/29/06 | at | Clemson | 94-85 2OT |
| 02/01/06 | hosting | Virginia | 66-64 |
| 02/05/06 | hosting | Maryland | 62-58 |
| 02/08/06 | at | Miami FL | 86-77 2OT |
| 02/12/06 | at | Georgia Tech | 68-71 |
| 02/15/06 | hosting | Florida St. | 86-64 |
| 02/18/06 | at | Virginia Tech | 70-64 |
| 02/22/06 | hosting | North Carolina | 71-95 |
| 02/25/06 | hosting | Boston College | 72-74 2OT |
| 03/04/06 | at | Wake Forest | 63-76 |
| 03/10/06 | vs. | Wake Forest | 71-82 |
| 03/17/06 | vs. | California | 58-52 |
| 03/19/06 | vs. | Texas | 54-75 |