| 11/18/05 | hosting | Texas Arlington | 74-65 |
| 11/20/05 | hosting | Jackson St. | 94-53 |
| 11/22/05 | hosting | Detroit | 90-56 |
| 11/25/05 | vs. | Texas Christian | 66-58 |
| 11/26/05 | vs. | Boston College | 68-76 |
| 11/30/05 | hosting | Nevada Las Vegas | 80-62 |
| 12/03/05 | hosting | Southern Methodist | 64-54 |
| 12/05/05 | hosting | Northwestern St. | 64-68 |
| 12/10/05 | vs. | Gonzaga | 62-64 |
| 12/18/05 | hosting | Mercer | 97-61 |
| 12/22/05 | vs. | Tennessee | 89-73 |
| 12/28/05 | at | UAB | 71-90 |
| 12/31/05 | hosting | Arkansas St. | 84-64 |
| 01/03/06 | at | Pepperdine | 69-49 |
| 01/07/06 | at | Missouri | 61-69 |
| 01/11/06 | hosting | Texas A&M | 79-77 |
| 01/14/06 | at | Baylor | 66-48 |
| 01/21/06 | hosting | Colorado | 78-80 OT |
| 01/23/06 | at | Texas | 46-80 |
| 01/28/06 | at | Texas Tech | 90-92 OT |
| 01/31/06 | hosting | Nebraska | 57-59 |
| 02/04/06 | at | Kansas St. | 63-61 |
| 02/08/06 | hosting | Oklahoma | 65-73 |
| 02/11/06 | at | Texas A&M | 44-46 |
| 02/13/06 | hosting | Kansas | 49-64 |
| 02/19/06 | hosting | Texas | 81-60 |
| 02/22/06 | at | Iowa St. | 52-68 |
| 02/25/06 | hosting | Texas Tech | 74-63 |
| 02/27/06 | at | Oklahoma | 66-67 |
| 03/04/06 | hosting | Baylor | 79-76 |
| 03/09/06 | vs. | Iowa St. | 79-70 |
| 03/10/06 | vs. | Kansas | 62-63 |
| 03/15/06 | at | Miami FL | 59-62 |