| 11/19/05 | hosting | Samford | 68-41 |
| 11/23/05 | hosting | Binghamton | 88-60 |
| 11/26/05 | hosting | Belmont | 81-59 |
| 11/30/05 | at | Tulsa | 62-53 |
| 12/03/05 | at | Villanova | 74-85 |
| 12/10/05 | hosting | Coppin St. | 57-47 |
| 12/17/05 | hosting | Southern | 68-54 |
| 12/22/05 | vs. | West Virginia | 68-92 |
| 12/28/05 | hosting | Oral Roberts | 81-73 |
| 12/31/05 | hosting | Alabama | 68-56 |
| 01/03/06 | at | Southern Methodist | 50-47 |
| 01/07/06 | at | Nebraska | 58-59 |
| 01/10/06 | hosting | Missouri | 69-71 |
| 01/14/06 | at | Texas A&M | 45-44 |
| 01/21/06 | hosting | Texas Tech | 60-48 |
| 01/25/06 | at | Baylor | 82-52 |
| 01/28/06 | hosting | Texas | 82-72 |
| 02/01/06 | hosting | Texas A&M | 71-63 |
| 02/05/06 | at | Kansas | 58-59 |
| 02/08/06 | at | Oklahoma St. | 73-65 |
| 02/11/06 | hosting | Baylor | 80-52 |
| 02/15/06 | at | Colorado | 75-84 |
| 02/18/06 | hosting | Iowa St. | 83-82 |
| 02/20/06 | at | Texas Tech | 71-70 |
| 02/25/06 | hosting | Kansas St. | 71-70 |
| 02/27/06 | hosting | Oklahoma St. | 67-66 |
| 03/05/06 | at | Texas | 48-72 |
| 03/10/06 | vs. | Nebraska | 63-69 |
| 03/16/06 | vs. | Wisconsin Milwaukee | 74-82 |