| 11/20/05 | hosting | Austin Peay | 66-46 |
| 11/22/05 | hosting | Delaware St. | 49-42 |
| 11/25/05 | vs. | Kent St. | 55-52 |
| 11/26/05 | vs. | Illinois | 57-77 |
| 11/30/05 | hosting | Temple | 67-53 |
| 12/03/05 | at | St. Mary's | 75-69 |
| 12/07/05 | hosting | Maryland Eastern Shore | 92-50 |
| 12/10/05 | at | Buffalo | 53-62 |
| 12/12/05 | hosting | St. Thomas Aquinas | 94-56 |
| 12/15/05 | hosting | Maine | 91-56 |
| 12/17/05 | hosting | South Carolina St. | 63-45 |
| 12/22/05 | hosting | Charlotte | 82-85 |
| 12/31/05 | hosting | Princeton | 54-44 |
| 01/07/06 | hosting | Seton Hall | 82-78 |
| 01/11/06 | hosting | Villanova | 78-84 OT |
| 01/15/06 | at | DePaul | 78-68 OT |
| 01/18/06 | hosting | Pittsburgh | 68-76 |
| 01/22/06 | at | Cincinnati | 66-71 |
| 01/25/06 | hosting | Providence | 69-79 |
| 01/28/06 | hosting | Louisville | 65-56 |
| 02/01/06 | at | Syracuse | 84-86 OT |
| 02/05/06 | at | Seton Hall | 67-73 |
| 02/08/06 | at | Notre Dame | 63-90 |
| 02/12/06 | hosting | Marquette | 91-84 |
| 02/15/06 | hosting | St. John's | 51-54 |
| 02/18/06 | at | South Florida | 65-51 |
| 02/22/06 | at | Georgetown | 50-66 |
| 02/26/06 | hosting | South Florida | 62-44 |
| 03/05/06 | at | St. John's | 82-70 |
| 03/08/06 | vs. | Seton Hall | 61-48 |
| 03/09/06 | vs. | Villanova | 55-87 |
| 03/14/06 | at | Penn St. | 76-71 |
| 03/16/06 | at | Saint Joseph's | 62-71 |