| 11/15/05 | hosting | Army | 69-37 |
| 11/17/05 | at | UCLA | 47-54 |
| 11/27/05 | hosting | Miami FL | 73-56 |
| 11/30/05 | at | Rutgers | 53-67 |
| 12/03/05 | at | Pennsylvania | 50-46 |
| 12/06/05 | at | Princeton | 60-47 |
| 12/10/05 | hosting | Alabama | 68-58 |
| 12/18/05 | at | Auburn | 42-73 |
| 12/22/05 | hosting | South Carolina | 63-50 |
| 12/31/05 | hosting | Villanova | 53-75 |
| 01/04/06 | hosting | George Washington | 60-72 |
| 01/08/06 | at | Saint Joseph's | 57-59 |
| 01/11/06 | at | St. Bonaventure | 83-66 |
| 01/14/06 | hosting | La Salle | 68-52 |
| 01/18/06 | at | Dayton | 53-51 |
| 01/21/06 | at | Massachusetts | 34-60 |
| 01/25/06 | hosting | Xavier | 81-79 |
| 01/28/06 | hosting | Maryland | 91-85 |
| 02/01/06 | hosting | Massachusetts | 76-47 |
| 02/04/06 | at | La Salle | 56-62 |
| 02/08/06 | at | Charlotte | 59-66 |
| 02/11/06 | hosting | Duquesne | 76-52 |
| 02/14/06 | hosting | Saint Joseph's | 57-44 |
| 02/18/06 | at | St. Louis | 51-56 |
| 02/22/06 | hosting | Richmond | 69-30 |
| 02/25/06 | hosting | Duke | 66-74 |
| 03/01/06 | at | Rhode Island | 63-69 |
| 03/05/06 | hosting | Fordham | 52-69 |
| 03/08/06 | vs. | Rhode Island | 74-45 |
| 03/09/06 | vs. | George Washington | 68-53 |
| 03/10/06 | vs. | Saint Joseph's | 59-73 |
| 03/14/06 | hosting | Akron | 73-80 OT |