| (50.05) | ||||
| 11/15/09 | hosting | Texas San Antonio | (48.44) | 50-62 |
| 11/17/09 | hosting | Duquesne | (51.52) | 50-52 |
| 11/20/09 | hosting | Bowling Green | (49.10) | 68-46 |
| 11/23/09 | vs. | Texas | (58.43) | 60-85 |
| 11/24/09 | vs. | Wichita St. | (55.16) | 57-74 |
| 11/28/09 | hosting | North Carolina Central | (40.86) | 73-63 |
| 12/01/09 | hosting | Virginia Tech | (56.25) | 64-70 |
| 12/05/09 | hosting | Prairie View A&M | (43.24) | 80-51 |
| 12/08/09 | at | Northern Iowa | (58.25) | 50-67 |
| 12/11/09 | at | Iowa St. | (54.52) | 71-81 |
| 12/19/09 | hosting | Drake | (50.74) | 71-67 |
| 12/21/09 | hosting | South Carolina St. | (45.87) | 82-69 |
| 12/29/09 | hosting | Purdue | (58.90) | 56-67 |
| 01/02/10 | hosting | Minnesota | (57.41) | 74-86 |
| 01/05/10 | at | Illinois | (56.12) | 42-59 |
| 01/09/10 | hosting | Michigan St. | (58.90) | 53-71 |
| 01/12/10 | hosting | Tennessee St. | (45.64) | 67-62 |
| 01/16/10 | hosting | Penn St. | (52.69) | 67-64 |
| 01/20/10 | at | Michigan St. | (58.90) | 63-70 |
| 01/24/10 | at | Indiana | (48.39) | 58-43 |
| 01/27/10 | hosting | Ohio St. | (60.55) | 57-65 |
| 01/30/10 | at | Michigan | (54.67) | 46-60 |
| 02/03/10 | hosting | Illinois | (56.12) | 49-57 |
| 02/07/10 | at | Ohio St. | (60.55) | 58-68 |
| 02/10/10 | hosting | Northwestern | (53.66) | 78-65 |
| 02/13/10 | at | Purdue | (58.90) | 40-63 |
| 02/16/10 | hosting | Michigan | (54.67) | 78-80 OT |
| 02/25/10 | at | Northwestern | (53.66) | 57-74 |
| 02/28/10 | hosting | Indiana | (48.39) | 73-57 |
| 03/03/10 | at | Wisconsin | (59.20) | 40-67 |
| 03/07/10 | at | Minnesota | (57.41) | 53-88 |
| 03/11/10 | vs. | Michigan | (54.67) | 52-59 |