| 10/14/05 | at | Michigan | 2-3 |
| 10/15/05 | at | Bowling Green | 9-6 |
| 10/22/05 | at | Northeastern | 1-1 OT |
| 10/28/05 | hosting | Maine | 1-2 |
| 10/29/05 | hosting | Providence | 3-2 |
| 11/01/05 | at | New Hampshire | 3-2 |
| 11/13/05 | at | Vermont | 2-1 |
| 11/15/05 | hosting | Harvard | 3-5 |
| 11/19/05 | hosting | Northeastern | 5-3 |
| 11/26/05 | hosting | Merrimack | 3-0 |
| 12/02/05 | hosting | Boston University | 2-1 |
| 12/03/05 | at | Boston University | 2-6 |
| 12/09/05 | hosting | Massachusetts | 7-0 |
| 12/10/05 | at | Massachusetts | 4-1 |
| 12/30/05 | vs. | Ferris State | 3-3 OT |
| 12/31/05 | vs. | Princeton | 5-1 |
| 01/06/06 | hosting | Northeastern | 4-3 |
| 01/07/06 | at | Providence | 4-1 |
| 01/13/06 | hosting | Merrimack | 2-1 |
| 01/14/06 | at | Merrimack | 5-0 |
| 01/20/06 | hosting | Vermont | 2-0 |
| 01/21/06 | hosting | Vermont | 3-0 |
| 01/27/06 | hosting | Boston University | 3-4 |
| 01/28/06 | at | Mass.-Lowell | 4-3 OT |
| 02/03/06 | at | Massachusetts | 2-3 |
| 02/06/06 | vs. | Northeastern | 5-2 |
| 02/10/06 | hosting | Providence | 8-3 |
| 02/13/06 | vs. | Boston University | 2-3 |
| 02/17/06 | at | Maine | 1-4 |
| 02/18/06 | at | Maine | 1-3 |
| 02/23/06 | hosting | Mass.-Lowell | 6-0 |
| 02/25/06 | at | Mass.-Lowell | 3-6 |
| 03/02/06 | hosting | New Hampshire | 3-3 OT |
| 03/04/06 | at | New Hampshire | 2-5 |
| 03/09/06 | hosting | Vermont | 3-2 OT |
| 03/10/06 | hosting | Vermont | 6-2 |
| 03/17/06 | vs. | Maine | 4-1 |
| 03/18/06 | vs. | Boston University | 1-2 OT |
| 03/24/06 | vs. | Miami | 5-0 |
| 03/25/06 | vs. | Boston University | 5-0 |
| 04/06/06 | vs. | North Dakota | 6-5 |
| 04/08/06 | vs. | Wisconsin | 1-2 |