| 10/14/05 | hosting | Merrimack | 2-3 |
| 10/15/05 | hosting | Boston College | 6-9 |
| 10/20/05 | hosting | Ohio State | 2-7 |
| 10/21/05 | at | Ohio State | 2-2 OT |
| 10/29/05 | at | Ferris State | 1-2 |
| 11/04/05 | hosting | Nebraska-Omaha | 7-3 |
| 11/05/05 | hosting | Nebraska-Omaha | 4-3 |
| 11/10/05 | at | Notre Dame | 4-9 |
| 11/11/05 | at | Notre Dame | 2-4 |
| 11/18/05 | hosting | Northern Michigan | 3-6 |
| 11/19/05 | hosting | Northern Michigan | 8-4 |
| 11/25/05 | at | Miami | 1-6 |
| 11/26/05 | hosting | Miami | 3-5 |
| 12/02/05 | at | Michigan State | 0-3 |
| 12/03/05 | hosting | Michigan State | 4-2 |
| 12/09/05 | hosting | Clarkson | 4-6 |
| 12/10/05 | hosting | St. Lawrence | 6-4 |
| 12/29/05 | vs. | Massachusetts | 3-2 |
| 12/30/05 | at | Connecticut | 9-2 |
| 01/03/06 | hosting | Colgate | 4-0 |
| 01/06/06 | at | Ohio State | 3-2 |
| 01/07/06 | hosting | Ohio State | 2-0 |
| 01/13/06 | hosting | Western Michigan | 4-5 |
| 01/14/06 | at | Western Michigan | 5-2 |
| 01/16/06 | hosting | Ferris State | 5-6 |
| 01/20/06 | at | Michigan | 1-6 |
| 01/21/06 | hosting | Michigan | 5-2 |
| 01/27/06 | at | Lake Superior | 1-6 |
| 01/28/06 | at | Lake Superior | 2-4 |
| 02/04/06 | hosting | RIT | 3-2 |
| 02/10/06 | at | Alaska-Fairbanks | 3-4 |
| 02/11/06 | at | Alaska-Fairbanks | 1-3 |
| 02/17/06 | hosting | Notre Dame | 4-7 |
| 02/18/06 | hosting | Notre Dame | 1-1 OT |
| 02/23/06 | hosting | Miami | 1-2 |
| 02/25/06 | at | Miami | 4-5 |
| 03/03/06 | at | Nebraska-Omaha | 2-4 |
| 03/04/06 | at | Nebraska-Omaha | 2-4 |