| 10/14/05 | vs. | New Hampshire | 2-4 |
| 10/15/05 | vs. | Army | 5-2 |
| 10/21/05 | at | Lake Superior | 4-4 OT |
| 10/22/05 | at | Lake Superior | 1-1 OT |
| 10/29/05 | hosting | Bowling Green | 2-1 |
| 11/04/05 | hosting | Alaska-Fairbanks | 2-5 |
| 11/05/05 | hosting | Alaska-Fairbanks | 3-3 OT |
| 11/08/05 | hosting | Michigan State | 2-2 OT |
| 11/11/05 | hosting | Western Michigan | 6-0 |
| 11/12/05 | at | Western Michigan | 5-3 |
| 11/18/05 | hosting | Bemidji State | 6-1 |
| 11/19/05 | hosting | Bemidji State | 3-4 |
| 11/25/05 | at | Mercyhurst | 6-3 |
| 11/26/05 | at | Mercyhurst | 5-4 |
| 12/02/05 | at | Nebraska-Omaha | 2-5 |
| 12/04/05 | at | Nebraska-Omaha | 3-5 |
| 12/09/05 | hosting | Northern Michigan | 5-3 |
| 12/10/05 | hosting | Northern Michigan | 1-2 |
| 12/30/05 | vs. | Boston College | 3-3 OT |
| 12/31/05 | at | Denver | 3-2 |
| 01/13/06 | at | Northern Michigan | 0-5 |
| 01/14/06 | at | Northern Michigan | 1-2 |
| 01/16/06 | at | Bowling Green | 6-5 |
| 01/20/06 | hosting | Lake Superior | 2-2 OT |
| 01/21/06 | hosting | Lake Superior | 3-1 |
| 01/24/06 | at | Michigan State | 2-1 |
| 01/27/06 | hosting | Miami | 1-3 |
| 01/28/06 | hosting | Miami | 0-5 |
| 02/03/06 | at | Western Michigan | 4-2 |
| 02/04/06 | hosting | Western Michigan | 7-2 |
| 02/10/06 | at | Notre Dame | 1-4 |
| 02/11/06 | hosting | Notre Dame | 2-3 |
| 02/17/06 | at | Ohio State | 3-3 OT |
| 02/18/06 | at | Ohio State | 2-3 |
| 02/24/06 | hosting | Michigan | 3-3 OT |
| 02/25/06 | at | Michigan | 4-3 OT |
| 03/03/06 | hosting | Ohio State | 3-0 |
| 03/04/06 | hosting | Ohio State | 2-1 |
| 03/10/06 | at | Michigan | 4-6 |
| 03/11/06 | at | Michigan | 2-3 |