| 10/08/05 | vs. | North Dakota | 0-3 |
| 10/09/05 | vs. | Wayne State | 4-0 |
| 10/21/05 | at | Nebraska-Omaha | 6-3 |
| 10/22/05 | at | Nebraska-Omaha | 3-2 |
| 11/04/05 | hosting | Ohio State | 3-1 |
| 11/05/05 | at | Ohio State | 4-1 |
| 11/11/05 | at | Lake Superior | 3-0 |
| 11/12/05 | at | Lake Superior | 2-3 |
| 11/18/05 | hosting | Notre Dame | 2-2 OT |
| 11/19/05 | hosting | Notre Dame | 3-0 |
| 11/25/05 | hosting | Bowling Green | 6-1 |
| 11/26/05 | at | Bowling Green | 5-3 |
| 12/02/05 | hosting | Michigan | 4-2 |
| 12/03/05 | hosting | Michigan | 4-3 |
| 12/09/05 | hosting | St. Lawrence | 1-1 OT |
| 12/10/05 | hosting | Clarkson | 2-1 |
| 12/29/05 | vs. | Rensselaer | 3-2 OT |
| 12/30/05 | at | Ohio State | 1-1 OT |
| 01/06/06 | hosting | Northern Michigan | 1-2 |
| 01/07/06 | hosting | Northern Michigan | 6-3 |
| 01/10/06 | at | Ohio State | 0-3 |
| 01/13/06 | at | Notre Dame | 2-2 OT |
| 01/14/06 | at | Notre Dame | 3-2 |
| 01/20/06 | hosting | Western Michigan | 6-1 |
| 01/21/06 | hosting | Western Michigan | 4-3 |
| 01/27/06 | at | Ferris State | 3-1 |
| 01/28/06 | at | Ferris State | 5-0 |
| 02/03/06 | hosting | Alaska-Fairbanks | 3-4 |
| 02/04/06 | hosting | Alaska-Fairbanks | 2-1 |
| 02/14/06 | hosting | Ohio State | 6-3 |
| 02/17/06 | at | Michigan State | 2-3 |
| 02/18/06 | at | Michigan State | 1-3 |
| 02/23/06 | at | Bowling Green | 2-1 |
| 02/25/06 | hosting | Bowling Green | 5-4 |
| 03/10/06 | hosting | Western Michigan | 4-1 |
| 03/11/06 | hosting | Western Michigan | 5-4 OT |
| 03/17/06 | vs. | Northern Michigan | 5-2 |
| 03/18/06 | vs. | Michigan State | 1-2 |
| 03/24/06 | vs. | Boston College | 0-5 |