| 10/14/05 | vs. | Michigan Tech | 4-3 OT |
| 10/15/05 | at | Alaska-Anchorage | 2-0 |
| 10/21/05 | hosting | Minnesota-Duluth | 5-1 |
| 10/22/05 | hosting | Minnesota-Duluth | 5-1 |
| 10/28/05 | at | Niagara | 3-2 |
| 10/29/05 | at | Niagara | 4-2 |
| 11/01/05 | at | Northeastern | 5-3 |
| 11/04/05 | at | Boston University | 2-4 |
| 11/11/05 | hosting | Providence | 6-2 |
| 11/13/05 | hosting | Boston College | 1-2 |
| 11/18/05 | at | Merrimack | 3-0 |
| 11/22/05 | hosting | Massachusetts | 1-2 |
| 11/27/05 | at | Maine | 2-1 |
| 12/02/05 | hosting | New Hampshire | 3-3 OT |
| 12/03/05 | hosting | Mass.-Lowell | 5-2 |
| 12/17/05 | hosting | St. Lawrence | 1-2 |
| 12/30/05 | hosting | Dartmouth | 1-0 |
| 12/31/05 | hosting | Clarkson | 3-0 |
| 01/06/06 | at | New Hampshire | 1-2 |
| 01/07/06 | at | New Hampshire | 2-2 OT |
| 01/13/06 | hosting | Northeastern | 3-0 |
| 01/14/06 | hosting | Northeastern | 3-0 |
| 01/20/06 | at | Boston College | 0-2 |
| 01/21/06 | at | Boston College | 0-3 |
| 01/27/06 | hosting | Merrimack | 2-4 |
| 01/28/06 | hosting | Merrimack | 4-3 OT |
| 02/03/06 | at | Providence | 4-1 |
| 02/04/06 | at | Providence | 3-3 OT |
| 02/10/06 | hosting | Maine | 1-3 |
| 02/11/06 | hosting | Maine | 4-4 OT |
| 02/17/06 | at | Massachusetts | 0-3 |
| 02/18/06 | at | Massachusetts | 3-2 OT |
| 02/24/06 | hosting | Boston University | 1-1 OT |
| 02/25/06 | hosting | Boston University | 2-2 OT |
| 03/03/06 | at | Mass.-Lowell | 2-3 |
| 03/04/06 | at | Mass.-Lowell | 2-5 |
| 03/09/06 | at | Boston College | 2-3 OT |
| 03/10/06 | at | Boston College | 2-6 |