| 10/15/05 | hosting | Robert Morris | 2-5 |
| 10/22/05 | at | Niagara | 2-3 |
| 10/28/05 | hosting | Ohio State | 5-1 |
| 10/29/05 | hosting | Ohio State | 5-4 |
| 11/04/05 | hosting | Lake Superior | 0-10 |
| 11/05/05 | hosting | Lake Superior | 1-3 |
| 11/11/05 | at | Ferris State | 0-6 |
| 11/12/05 | hosting | Ferris State | 3-5 |
| 11/18/05 | at | Michigan State | 3-3 OT |
| 11/19/05 | hosting | Michigan State | 5-3 |
| 11/25/05 | at | Colgate | 2-2 OT |
| 11/26/05 | at | Colgate | 3-4 OT |
| 12/02/05 | hosting | Notre Dame | 4-3 |
| 12/03/05 | at | Notre Dame | 0-3 |
| 12/17/05 | at | Northern Michigan | 0-0 OT |
| 12/18/05 | at | Northern Michigan | 2-5 |
| 12/30/05 | at | Wisconsin | 1-4 |
| 12/31/05 | vs. | Wayne State | 3-6 |
| 01/06/06 | at | Lake Superior | 1-6 |
| 01/07/06 | at | Lake Superior | 0-4 |
| 01/13/06 | at | Bowling Green | 5-4 |
| 01/14/06 | hosting | Bowling Green | 2-5 |
| 01/20/06 | at | Miami | 1-6 |
| 01/21/06 | at | Miami | 3-4 |
| 01/27/06 | hosting | Northern Michigan | 4-2 |
| 01/28/06 | hosting | Northern Michigan | 2-2 OT |
| 01/31/06 | at | Michigan | 3-7 |
| 02/03/06 | hosting | Ferris State | 2-4 |
| 02/04/06 | at | Ferris State | 2-7 |
| 02/07/06 | hosting | Michigan | 1-4 |
| 02/10/06 | hosting | Bemidji State | 1-6 |
| 02/11/06 | hosting | Bemidji State | 5-4 OT |
| 02/17/06 | at | Alaska-Fairbanks | 1-1 OT |
| 02/18/06 | at | Alaska-Fairbanks | 3-5 |
| 02/24/06 | hosting | Nebraska-Omaha | 5-5 OT |
| 02/25/06 | hosting | Nebraska-Omaha | 6-3 |
| 03/03/06 | at | Lake Superior | 3-2 OT |
| 03/04/06 | at | Lake Superior | 1-0 |
| 03/10/06 | at | Miami | 1-4 |
| 03/11/06 | at | Miami | 4-5 OT |