| 04/02/05 | at | Chivas USA | 2-0 |
| 04/09/05 | hosting | Chicago Fire | 1-1 |
| 04/15/05 | at | Columbus Crew | 0-1 |
| 04/23/05 | hosting | New England Revolution | 3-4 |
| 04/30/05 | at | Kansas City Wizards | 0-0 |
| 05/07/05 | hosting | Columbus Crew | 3-1 |
| 05/14/05 | at | New England Revolution | 0-1 |
| 05/21/05 | hosting | Kansas City Wizards | 3-2 |
| 05/28/05 | hosting | FC Dallas | 0-2 |
| 06/04/05 | at | San Jose Earthquakes | 0-0 |
| 06/12/05 | at | MetroStars | 0-0 |
| 06/15/05 | hosting | Chicago Fire | 4-3 |
| 06/18/05 | hosting | New England Revolution | 2-0 |
| 06/29/05 | at | Chicago Fire | 3-4 |
| 07/02/05 | at | Columbus Crew | 1-0 |
| 07/09/05 | hosting | Kansas City Wizards | 0-1 |
| 07/15/05 | hosting | San Jose Earthquakes | 3-0 |
| 07/20/05 | at | Kansas City Wizards | 1-1 |
| 07/23/05 | at | Los Angeles Galaxy | 1-0 |
| 08/06/05 | at | Chicago Fire | 3-2 |
| 08/10/05 | hosting | MetroStars | 3-0 |
| 08/13/05 | hosting | Chivas USA | 3-0 |
| 08/20/05 | hosting | Los Angeles Galaxy | 2-3 |
| 08/27/05 | at | New England Revolution | 1-2 |
| 08/31/05 | hosting | Real Salt Lake | 5-1 |
| 09/03/05 | at | Colorado Rapids | 0-1 |
| 09/10/05 | at | FC Dallas | 2-1 |
| 09/17/05 | hosting | Colorado Rapids | 2-0 |
| 10/01/05 | at | MetroStars | 4-1 |
| 10/05/05 | at | Real Salt Lake | 3-1 |
| 10/08/05 | hosting | MetroStars | 1-2 |
| 10/15/05 | hosting | Columbus Crew | 2-2 |
| 10/21/05 | at | Chicago Fire | 0-0 |
| 10/30/05 | hosting | Chicago Fire | 0-4 |