| (50.55) | ||||
| 03/27/10 | hosting | Chicago Fire | (49.56) | 1-0 |
| 04/03/10 | at | Seattle Sounders FC | (50.33) | 1-0 |
| 04/10/10 | at | Chivas USA | (48.13) | 0-2 |
| 04/17/10 | hosting | FC Dallas | (51.49) | 2-1 |
| 04/24/10 | hosting | Philadelphia Union | (48.67) | 2-1 |
| 05/01/10 | at | D.C. United | (48.31) | 2-0 |
| 05/08/10 | at | San Jose Earthquakes | (49.97) | 0-4 |
| 05/15/10 | hosting | Seattle Sounders FC | (50.33) | 0-1 |
| 05/20/10 | hosting | Columbus Crew | (49.86) | 1-3 |
| 05/29/10 | at | New England Revolution | (49.02) | 2-3 |
| 06/02/10 | hosting | Houston Dynamo | (49.16) | 2-1 |
| 06/05/10 | hosting | Chivas USA | (48.13) | 1-0 |
| 06/26/10 | at | Kansas City Wizards | (50.22) | 3-0 |
| 07/04/10 | at | Colorado Rapids | (50.66) | 1-1 |
| 07/10/10 | hosting | D.C. United | (48.31) | 0-0 |
| 07/17/10 | at | Columbus Crew | (49.86) | 0-2 |
| 07/31/10 | at | Houston Dynamo | (49.16) | 2-2 |
| 08/08/10 | at | Chicago Fire | (49.56) | 0-0 |
| 08/11/10 | hosting | Toronto FC | (48.90) | 1-0 |
| 08/14/10 | hosting | Los Angeles Galaxy | (50.00) | 0-1 |
| 08/21/10 | at | Toronto FC | (48.90) | 4-1 |
| 08/28/10 | hosting | San Jose Earthquakes | (49.97) | 2-0 |
| 09/04/10 | at | Real Salt Lake | (51.31) | 0-1 |
| 09/11/10 | hosting | Colorado Rapids | (50.66) | 3-1 |
| 09/16/10 | at | FC Dallas | (51.49) | 2-2 |
| 09/24/10 | at | Los Angeles Galaxy | (50.00) | 2-0 |
| 10/02/10 | hosting | Kansas City Wizards | (50.22) | 1-0 |
| 10/09/10 | hosting | Real Salt Lake | (51.31) | 0-0 |
| 10/16/10 | at | Philadelphia Union | (48.67) | 1-2 |
| 10/21/10 | hosting | New England Revolution | (49.02) | 2-0 |
| 10/30/10 | at | San Jose Earthquakes | (49.97) | 1-0 |
| 11/04/10 | hosting | San Jose Earthquakes | (49.97) | 1-3 |