| 09/10/06 | at | New England | 17-19 |
| 09/17/06 | at | Miami | 16-6 |
| 09/24/06 | hosting | N.Y. Jets | 20-28 |
| 10/01/06 | hosting | Minnesota | 17-12 |
| 10/08/06 | at | Chicago | 7-40 |
| 10/15/06 | at | Detroit | 17-20 |
| 10/22/06 | hosting | New England | 6-28 |
| 11/05/06 | hosting | Green Bay | 24-10 |
| 11/12/06 | at | Indianapolis | 16-17 |
| 11/19/06 | at | Houston | 24-21 |
| 11/26/06 | hosting | Jacksonville | 27-24 |
| 12/03/06 | hosting | San Diego | 21-24 |
| 12/10/06 | at | N.Y. Jets | 31-13 |
| 12/17/06 | hosting | Miami | 21-0 |
| 12/24/06 | hosting | Tennessee | 29-30 |
| 12/31/06 | at | Baltimore | 7-19 |