| 09/10/06 | hosting | Atlanta | 6-20 |
| 09/17/06 | at | Minnesota | 13-16 OT |
| 09/24/06 | at | Tampa Bay | 26-24 |
| 10/01/06 | hosting | New Orleans | 21-18 |
| 10/08/06 | hosting | Cleveland | 20-12 |
| 10/15/06 | at | Baltimore | 23-21 |
| 10/22/06 | at | Cincinnati | 14-17 |
| 10/29/06 | hosting | Dallas | 14-35 |
| 11/13/06 | hosting | Tampa Bay | 24-10 |
| 11/19/06 | hosting | St. Louis | 15-0 |
| 11/26/06 | at | Washington | 13-17 |
| 12/04/06 | at | Philadelphia | 24-27 |
| 12/10/06 | hosting | N.Y. Giants | 13-27 |
| 12/17/06 | hosting | Pittsburgh | 3-37 |
| 12/24/06 | at | Atlanta | 10-3 |
| 12/31/06 | at | New Orleans | 31-21 |