| 09/10/06 | hosting | Philadelphia | 10-24 |
| 09/17/06 | at | Indianapolis | 24-43 |
| 09/24/06 | hosting | Washington | 15-31 |
| 10/01/06 | hosting | Miami | 17-15 |
| 10/15/06 | at | Dallas | 6-34 |
| 10/22/06 | hosting | Jacksonville | 27-7 |
| 10/29/06 | at | Tennessee | 22-28 |
| 11/05/06 | at | N.Y. Giants | 10-14 |
| 11/12/06 | at | Jacksonville | 13-10 |
| 11/19/06 | hosting | Buffalo | 21-24 |
| 11/26/06 | at | N.Y. Jets | 11-26 |
| 12/03/06 | at | Oakland | 23-14 |
| 12/10/06 | hosting | Tennessee | 20-26 OT |
| 12/17/06 | at | New England | 7-40 |
| 12/24/06 | hosting | Indianapolis | 27-24 |
| 12/31/06 | hosting | Cleveland | 14-6 |