| 09/10/06 | hosting | Indianapolis | 21-26 |
| 09/17/06 | at | Philadelphia | 30-24 OT |
| 09/24/06 | at | Seattle | 30-42 |
| 10/08/06 | hosting | Washington | 19-3 |
| 10/15/06 | at | Atlanta | 27-14 |
| 10/23/06 | at | Dallas | 36-22 |
| 10/29/06 | hosting | Tampa Bay | 17-3 |
| 11/05/06 | hosting | Houston | 14-10 |
| 11/12/06 | hosting | Chicago | 20-38 |
| 11/20/06 | at | Jacksonville | 10-26 |
| 11/26/06 | at | Tennessee | 21-24 |
| 12/03/06 | hosting | Dallas | 20-23 |
| 12/10/06 | at | Carolina | 27-13 |
| 12/17/06 | hosting | Philadelphia | 22-36 |
| 12/24/06 | hosting | New Orleans | 7-30 |
| 12/30/06 | at | Washington | 34-28 |
| 01/07/07 | at | Philadelphia | 20-23 |