| 09/10/06 | at | Tennessee | 23-16 |
| 09/17/06 | hosting | New England | 17-24 |
| 09/24/06 | at | Buffalo | 28-20 |
| 10/01/06 | hosting | Indianapolis | 28-31 |
| 10/08/06 | at | Jacksonville | 0-41 |
| 10/15/06 | hosting | Miami | 20-17 |
| 10/22/06 | hosting | Detroit | 31-24 |
| 10/29/06 | at | Cleveland | 13-20 |
| 11/12/06 | at | New England | 17-14 |
| 11/19/06 | hosting | Chicago | 0-10 |
| 11/26/06 | hosting | Houston | 26-11 |
| 12/03/06 | at | Green Bay | 38-10 |
| 12/10/06 | hosting | Buffalo | 13-31 |
| 12/17/06 | at | Minnesota | 26-13 |
| 12/25/06 | at | Miami | 13-10 |
| 12/31/06 | hosting | Oakland | 23-3 |
| 01/07/07 | at | New England | 16-37 |