| 09/10/06 | hosting | N.Y. Jets | 16-23 |
| 09/17/06 | at | San Diego | 7-40 |
| 09/24/06 | at | Miami | 10-13 |
| 10/01/06 | hosting | Dallas | 14-45 |
| 10/08/06 | at | Indianapolis | 13-14 |
| 10/15/06 | at | Washington | 25-22 |
| 10/29/06 | hosting | Houston | 28-22 |
| 11/05/06 | at | Jacksonville | 7-37 |
| 11/12/06 | hosting | Baltimore | 26-27 |
| 11/19/06 | at | Philadelphia | 31-13 |
| 11/26/06 | hosting | N.Y. Giants | 24-21 |
| 12/03/06 | hosting | Indianapolis | 20-17 |
| 12/10/06 | at | Houston | 26-20 OT |
| 12/17/06 | hosting | Jacksonville | 24-17 |
| 12/24/06 | at | Buffalo | 30-29 |
| 12/31/06 | hosting | New England | 23-40 |