| 09/11/06 | hosting | Minnesota | 16-19 |
| 09/17/06 | at | Dallas | 10-27 |
| 09/24/06 | at | Houston | 31-15 |
| 10/01/06 | hosting | Jacksonville | 36-30 OT |
| 10/08/06 | at | N.Y. Giants | 3-19 |
| 10/15/06 | hosting | Tennessee | 22-25 |
| 10/22/06 | at | Indianapolis | 22-36 |
| 11/05/06 | hosting | Dallas | 22-19 |
| 11/12/06 | at | Philadelphia | 3-27 |
| 11/19/06 | at | Tampa Bay | 17-20 |
| 11/26/06 | hosting | Carolina | 17-13 |
| 12/03/06 | hosting | Atlanta | 14-24 |
| 12/10/06 | hosting | Philadelphia | 19-21 |
| 12/17/06 | at | New Orleans | 16-10 |
| 12/24/06 | at | St. Louis | 31-37 OT |
| 12/30/06 | hosting | N.Y. Giants | 28-34 |