| (50.09) | ||||
| 09/07/08 | at | Pittsburgh | (53.51) | 17-38 |
| 09/21/08 | at | Tennessee | (52.11) | 12-31 |
| 09/28/08 | at | Jacksonville | (47.80) | 27-30 OT |
| 10/05/08 | hosting | Indianapolis | (52.21) | 27-31 |
| 10/12/08 | hosting | Miami | (50.61) | 29-28 |
| 10/19/08 | hosting | Detroit | (43.56) | 28-21 |
| 10/26/08 | hosting | Cincinnati | (49.04) | 35-6 |
| 11/02/08 | at | Minnesota | (50.49) | 21-28 |
| 11/09/08 | hosting | Baltimore | (53.39) | 13-41 |
| 11/16/08 | at | Indianapolis | (52.21) | 27-33 |
| 11/23/08 | at | Cleveland | (47.97) | 16-6 |
| 12/01/08 | hosting | Jacksonville | (47.80) | 30-17 |
| 12/07/08 | at | Green Bay | (49.10) | 24-21 |
| 12/14/08 | hosting | Tennessee | (52.11) | 13-12 |
| 12/21/08 | at | Oakland | (48.11) | 16-27 |
| 12/28/08 | hosting | Chicago | (49.64) | 31-24 |