| (46.39) | ||||
| 09/07/08 | at | New England | (52.09) | 10-17 |
| 09/14/08 | hosting | Oakland | (48.43) | 8-23 |
| 09/21/08 | at | Atlanta | (51.15) | 14-38 |
| 09/28/08 | hosting | Denver | (48.23) | 33-19 |
| 10/05/08 | at | Carolina | (51.64) | 0-34 |
| 10/19/08 | hosting | Tennessee | (52.47) | 10-34 |
| 10/26/08 | at | N.Y. Jets | (49.13) | 24-28 |
| 11/02/08 | hosting | Tampa Bay | (49.37) | 27-30 OT |
| 11/09/08 | at | San Diego | (51.05) | 19-20 |
| 11/16/08 | hosting | New Orleans | (50.31) | 20-30 |
| 11/23/08 | hosting | Buffalo | (48.28) | 31-54 |
| 11/30/08 | at | Oakland | (48.43) | 20-13 |
| 12/07/08 | at | Denver | (48.23) | 17-24 |
| 12/14/08 | hosting | San Diego | (51.05) | 21-22 |
| 12/21/08 | hosting | Miami | (50.72) | 31-38 |
| 12/28/08 | at | Cincinnati | (49.17) | 6-16 |