| (49.11) | ||||
| 09/07/08 | at | Miami | (50.61) | 20-14 |
| 09/14/08 | hosting | New England | (52.17) | 10-19 |
| 09/22/08 | at | San Diego | (50.67) | 29-48 |
| 09/28/08 | hosting | Arizona | (51.09) | 56-35 |
| 10/12/08 | hosting | Cincinnati | (49.04) | 26-14 |
| 10/19/08 | at | Oakland | (48.11) | 13-16 OT |
| 10/26/08 | hosting | Kansas City | (46.16) | 28-24 |
| 11/02/08 | at | Buffalo | (48.24) | 26-17 |
| 11/09/08 | hosting | St. Louis | (46.25) | 47-3 |
| 11/13/08 | at | New England | (52.17) | 34-31 OT |
| 11/23/08 | at | Tennessee | (52.11) | 34-13 |
| 11/30/08 | hosting | Denver | (47.91) | 17-34 |
| 12/07/08 | at | San Francisco | (48.65) | 14-24 |
| 12/14/08 | hosting | Buffalo | (48.24) | 31-27 |
| 12/21/08 | at | Seattle | (48.22) | 3-13 |
| 12/28/08 | hosting | Miami | (50.61) | 17-24 |