| (52.09) | ||||
| 09/07/08 | hosting | Kansas City | (46.39) | 17-10 |
| 09/14/08 | at | N.Y. Jets | (49.13) | 19-10 |
| 09/21/08 | hosting | Miami | (50.72) | 13-38 |
| 10/05/08 | at | San Francisco | (48.63) | 30-21 |
| 10/12/08 | at | San Diego | (51.05) | 10-30 |
| 10/20/08 | hosting | Denver | (48.23) | 41-7 |
| 10/26/08 | hosting | St. Louis | (46.17) | 23-16 |
| 11/02/08 | at | Indianapolis | (52.44) | 15-18 |
| 11/09/08 | hosting | Buffalo | (48.28) | 20-10 |
| 11/13/08 | hosting | N.Y. Jets | (49.13) | 31-34 OT |
| 11/23/08 | at | Miami | (50.72) | 48-28 |
| 11/30/08 | hosting | Pittsburgh | (52.96) | 10-33 |
| 12/07/08 | at | Seattle | (48.05) | 24-21 |
| 12/14/08 | at | Oakland | (48.43) | 49-26 |
| 12/21/08 | hosting | Arizona | (49.98) | 47-7 |
| 12/28/08 | at | Buffalo | (48.28) | 13-0 |