| (49.90) | ||||
| 09/07/08 | hosting | Tampa Bay | (48.97) | 24-20 |
| 09/14/08 | at | Washington | (49.64) | 24-29 |
| 09/21/08 | at | Denver | (47.91) | 32-34 |
| 09/28/08 | hosting | San Francisco | (48.65) | 31-17 |
| 10/06/08 | hosting | Minnesota | (50.49) | 27-30 |
| 10/12/08 | hosting | Oakland | (48.11) | 34-3 |
| 10/19/08 | at | Carolina | (50.53) | 7-30 |
| 10/26/08 | hosting | San Diego | (50.67) | 37-32 |
| 11/09/08 | at | Atlanta | (50.90) | 20-34 |
| 11/16/08 | at | Kansas City | (46.16) | 30-20 |
| 11/24/08 | hosting | Green Bay | (49.10) | 51-29 |
| 11/30/08 | at | Tampa Bay | (48.97) | 20-23 |
| 12/07/08 | hosting | Atlanta | (50.90) | 29-25 |
| 12/11/08 | at | Chicago | (49.64) | 24-27 OT |
| 12/21/08 | at | Detroit | (43.56) | 42-7 |
| 12/28/08 | hosting | Carolina | (50.53) | 31-33 |