| (48.65) | ||||
| 09/07/08 | hosting | Arizona | (51.09) | 13-23 |
| 09/14/08 | at | Seattle | (48.22) | 33-30 OT |
| 09/21/08 | hosting | Detroit | (43.56) | 31-13 |
| 09/28/08 | at | New Orleans | (49.90) | 17-31 |
| 10/05/08 | hosting | New England | (52.17) | 21-30 |
| 10/12/08 | hosting | Philadelphia | (52.57) | 26-40 |
| 10/19/08 | at | N.Y. Giants | (51.87) | 17-29 |
| 10/26/08 | hosting | Seattle | (48.22) | 13-34 |
| 11/10/08 | at | Arizona | (51.09) | 24-29 |
| 11/16/08 | hosting | St. Louis | (46.25) | 35-16 |
| 11/23/08 | at | Dallas | (50.85) | 22-35 |
| 11/30/08 | at | Buffalo | (48.24) | 10-3 |
| 12/07/08 | hosting | N.Y. Jets | (49.11) | 24-14 |
| 12/14/08 | at | Miami | (50.61) | 9-14 |
| 12/21/08 | at | St. Louis | (46.25) | 17-16 |
| 12/28/08 | hosting | Washington | (49.64) | 27-24 |