| 10/07/05 | hosting | Boston University | 4-3 |
| 10/14/05 | hosting | Ohio State | 0-3 |
| 10/15/05 | hosting | Ohio State | 2-6 |
| 10/19/05 | at | Quinnipiac | 2-3 OT |
| 10/23/05 | at | Maine | 1-1 OT |
| 10/26/05 | hosting | Boston University | 2-4 |
| 10/29/05 | hosting | Providence | 1-5 |
| 10/30/05 | at | Providence | 1-6 |
| 11/05/05 | at | Clarkson | 2-5 |
| 11/06/05 | at | St. Lawrence | 0-3 |
| 11/12/05 | hosting | Vermont | 0-1 |
| 11/13/05 | hosting | Connecticut | 3-2 |
| 11/19/05 | hosting | New Hampshire | 2-8 |
| 11/22/05 | at | New Hampshire | 0-2 |
| 11/29/05 | hosting | Brown | 4-2 |
| 12/03/05 | hosting | Maine | 4-2 |
| 12/04/05 | hosting | Maine | 2-3 |
| 12/10/05 | at | Boston College | 4-5 |
| 01/07/06 | at | Yale | 0-3 |
| 01/09/06 | hosting | Boston College | 1-2 |
| 01/13/06 | hosting | Rensselaer | 1-3 |
| 01/17/06 | at | Boston College | 1-2 |
| 01/21/06 | at | Providence | 4-5 OT |
| 01/28/06 | hosting | Connecticut | 2-3 |
| 01/29/06 | at | Connecticut | 1-10 |
| 02/04/06 | at | Boston University | 4-3 |
| 02/07/06 | vs. | Boston College | 3-4 OT |
| 02/11/06 | hosting | New Hampshire | 1-11 |
| 02/14/06 | vs. | Boston University | 1-3 |
| 02/18/06 | at | Vermont | 2-1 |
| 02/19/06 | at | Vermont | 3-0 |
| 02/25/06 | hosting | Niagara | 3-0 |
| 02/26/06 | hosting | Niagara | 2-5 |