| 10/01/05 | hosting | Sacred Heart | 3-3 OT |
| 10/07/05 | hosting | Clarkson | 1-3 |
| 10/08/05 | hosting | Clarkson | 0-2 |
| 10/15/05 | at | Wisconsin | 0-5 |
| 10/16/05 | at | Wisconsin | 0-5 |
| 10/22/05 | hosting | Boston University | 3-3 OT |
| 10/23/05 | hosting | Boston University | 1-4 |
| 10/29/05 | vs. | Niagara | 1-3 |
| 10/30/05 | vs. | Princeton | 1-2 OT |
| 11/05/05 | hosting | Robert Morris | 1-2 |
| 11/06/05 | hosting | Robert Morris | 3-1 |
| 11/12/05 | at | Northeastern | 1-0 |
| 11/13/05 | at | Boston University | 1-3 |
| 11/17/05 | at | Providence | 1-6 |
| 11/27/05 | hosting | Quinnipiac | 0-1 |
| 12/01/05 | at | Connecticut | 0-4 |
| 12/04/05 | hosting | New Hampshire | 1-4 |
| 01/01/06 | hosting | Connecticut | 1-2 |
| 01/02/06 | hosting | Connecticut | 0-3 |
| 01/06/06 | hosting | North Dakota | 2-3 |
| 01/07/06 | hosting | North Dakota | 2-3 OT |
| 01/12/06 | at | Boston College | 1-3 |
| 01/13/06 | at | Boston College | 0-3 |
| 01/16/06 | hosting | Boston College | 0-2 |
| 01/21/06 | hosting | Maine | 0-2 |
| 01/29/06 | hosting | Rensselaer | 4-3 |
| 02/04/06 | hosting | Providence | 1-4 |
| 02/05/06 | hosting | Providence | 1-5 |
| 02/11/06 | at | Maine | 0-7 |
| 02/12/06 | at | Maine | 0-3 |
| 02/18/06 | hosting | Northeastern | 1-2 |
| 02/19/06 | hosting | Northeastern | 0-3 |
| 02/25/06 | at | New Hampshire | 0-5 |
| 02/26/06 | at | New Hampshire | 0-8 |