| 09/03/05 | at | Wittenberg | 54-0 |
| 09/17/05 | at | Otterbein | 14-17 |
| 09/24/05 | hosting | Heidelberg | 66-0 |
| 10/01/05 | at | Mount Union | 24-42 |
| 10/08/05 | hosting | Marietta | 41-10 |
| 10/15/05 | at | Muskingum | 30-13 |
| 10/22/05 | hosting | Baldwin-Wallace | 34-0 |
| 10/29/05 | at | Ohio Northern | 16-14 |
| 11/05/05 | hosting | John Carroll | 19-7 |
| 11/12/05 | hosting | Wilmington | 48-10 |
| 11/19/05 | at | North Central | 21-19 |
| 11/26/05 | at | Wabash | 14-11 |
| 12/03/05 | at | Mount Union | 31-34 |