| 08/31/06 | at | Ball St | 20-38 |
| 09/09/06 | at | Michigan St | 20-52 |
| 09/16/06 | at | Northwestern | 6-14 |
| 09/23/06 | hosting | Central Michigan | 17-24 OT |
| 09/30/06 | at | Louisiana-Lafayette | 14-33 |
| 10/14/06 | at | Bowling Green | 21-24 |
| 10/21/06 | hosting | Toledo | 17-13 |
| 10/28/06 | at | Western Michigan | 15-18 |
| 11/04/06 | hosting | Ohio U. | 10-16 |
| 11/11/06 | hosting | Navy | 21-49 |
| 11/17/06 | at | Kent St | 6-14 |
| 11/24/06 | hosting | Northern Illinois | 0-27 |