| 11/19/05 | at | Duke | 55-84 |
| 11/22/05 | hosting | Massachusetts | 66-63 |
| 11/26/05 | hosting | Saint Joseph's | 100-94 OT |
| 11/30/05 | at | Charlotte | 81-85 2OT |
| 12/03/05 | at | Appalachian St. | 102-69 |
| 12/07/05 | hosting | Missouri | 82-73 |
| 12/10/05 | hosting | Catholic | 80-56 |
| 12/15/05 | hosting | St. Mary's MD | 112-59 |
| 12/18/05 | at | Syracuse | 80-90 |
| 12/21/05 | hosting | Clark MA | 108-57 |
| 12/29/05 | at | Illinois Chicago | 67-76 |
| 01/03/06 | at | North Carolina | 58-82 |
| 01/07/06 | hosting | Wofford | 80-62 |
| 01/10/06 | hosting | The Citadel | 85-49 |
| 01/14/06 | at | Furman | 66-70 |
| 01/17/06 | at | College of Charleston | 80-70 |
| 01/21/06 | hosting | Georgia Southern | 83-58 |
| 01/23/06 | at | Chattanooga | 59-65 |
| 01/27/06 | hosting | Elon | 79-60 |
| 01/29/06 | hosting | Princeton | 65-50 |
| 02/04/06 | hosting | Western Carolina | 70-77 |
| 02/08/06 | hosting | NC Greensboro | 92-73 |
| 02/11/06 | at | Wofford | 71-84 |
| 02/13/06 | at | The Citadel | 81-77 |
| 02/18/06 | hosting | Furman | 77-59 |
| 02/21/06 | at | Georgia Southern | 73-76 |
| 02/25/06 | hosting | College of Charleston | 65-63 |
| 03/03/06 | at | The Citadel | 79-73 |
| 03/04/06 | vs. | Elon | 65-58 |
| 03/05/06 | vs. | Chattanooga | 80-55 |
| 03/17/06 | vs. | Ohio St. | 62-70 |