| 11/22/05 | hosting | Arkansas Pine Bluff | 56-64 |
| 11/26/05 | at | Oakland | 53-77 |
| 11/30/05 | at | Akron | 61-79 |
| 12/03/05 | hosting | Robert Morris | 73-58 |
| 12/07/05 | hosting | Pittsburgh | 60-71 |
| 12/10/05 | at | West Virginia | 66-86 |
| 12/17/05 | at | Youngstown St. | 51-72 |
| 12/20/05 | hosting | The Citadel | 90-61 |
| 12/27/05 | hosting | Boston College | 69-81 |
| 12/30/05 | hosting | Troy | 72-78 |
| 12/31/05 | hosting | Appalachian St. | 68-71 |
| 01/04/06 | at | La Salle | 61-84 |
| 01/07/06 | hosting | Massachusetts | 63-82 |
| 01/11/06 | hosting | Richmond | 48-62 |
| 01/15/06 | at | Fordham | 63-90 |
| 01/21/06 | at | Dayton | 63-85 |
| 01/25/06 | hosting | George Washington | 78-94 |
| 01/28/06 | at | St. Bonaventure | 86-82 |
| 02/01/06 | hosting | La Salle | 66-75 |
| 02/04/06 | hosting | Fordham | 81-90 |
| 02/08/06 | at | Rhode Island | 69-79 |
| 02/11/06 | at | Temple | 52-76 |
| 02/15/06 | hosting | St. Louis | 57-70 |
| 02/18/06 | at | Xavier | 70-91 |
| 02/25/06 | hosting | St. Bonaventure | 76-77 |
| 03/01/06 | at | Charlotte | 71-77 |
| 03/04/06 | hosting | Saint Joseph's | 63-79 |