| 11/13/05 | vs. | Lehigh | 61-59 |
| 11/14/05 | vs. | Charlotte | 61-47 |
| 11/15/05 | vs. | NC Wilmington | 48-56 |
| 11/21/05 | hosting | Florida Atlantic | 69-59 |
| 11/26/05 | at | DePaul | 49-59 |
| 11/30/05 | at | Virginia | 57-72 |
| 12/03/05 | hosting | Delaware St. | 61-54 OT |
| 12/14/05 | hosting | Illinois Chicago | 62-71 |
| 12/18/05 | at | Seton Hall | 44-42 |
| 12/23/05 | hosting | DePauw | 69-36 |
| 01/01/06 | hosting | Northern Colorado | 82-47 |
| 01/04/06 | hosting | Purdue | 66-53 |
| 01/07/06 | at | Minnesota | 57-49 |
| 01/11/06 | hosting | Penn St. | 61-65 |
| 01/14/06 | at | Wisconsin | 52-68 |
| 01/18/06 | at | Michigan | 51-68 |
| 01/21/06 | hosting | Illinois | 47-58 |
| 01/25/06 | at | Purdue | 78-76 OT |
| 02/01/06 | at | Indiana | 63-72 |
| 02/04/06 | hosting | Michigan St. | 66-77 |
| 02/08/06 | hosting | Iowa | 51-48 |
| 02/11/06 | hosting | IUPU Fort Wayne | 73-49 |
| 02/15/06 | at | Illinois | 47-63 |
| 02/18/06 | at | Ohio St. | 52-61 |
| 02/23/06 | hosting | Wisconsin | 62-51 |
| 02/25/06 | at | Penn St. | 55-68 |
| 03/01/06 | hosting | Ohio St. | 53-56 |
| 03/04/06 | hosting | Minnesota | 57-53 |
| 03/09/06 | vs. | Penn St. | 42-60 |